ea0081oc10.3 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022
Allard Camille
, Zizzari Philippe
, Clark Samantha
, Dupuy Nathalie
, Bermudez-Silva Francisco-Javier
, Delgado Concepcion Lillo
, Bellocchio Luigi
, Marsicano Giovanni
, Quarta Carmelo
, Cota Daniela
Type 2 diabetes is among the most prevalent chronic diseases worldwide. Further research is needed to identify new mechanisms that may help preserve the function of insulin-secreting pancreatic β-cells. The cannabinoid receptors type 1 (CB1) and their endogenous ligands, endocannabinoids, exert a key role in regulating of glucose homeostasis, β-cells function, and insulin secretion. Intriguingly, CB1 is not only located at the plasma membrane (pmCB1), but also at the...